The requisite sign of addiction is withdrawal-which is just the body in a state of opioid/pleasure chemical deficit before it is able to adjust the level of production back toward a normal range. When that occurs, the acute stage of withdrawal completes itself.
Withdrawal is not a syndrome, it is the direct symptom of a body's physical dependence on an outer supply of opioids. "Post withdrawal" is injury from damage inflicted before and during addiction, that ends when those injuries heal sufficiently.
A syndrome by the way is a collection of related symptoms that have no recognised or definite source or cause. "Cravings" are the body craving restortion of normal levels of (pleasure) chemical function.
Addiction is a bit like a process of going from a wholly inner supply, to less of that topped up by an outer supply. When you stop "topping" you enter withdrawal, 'recovery' is when the body goes back toward prior production levels.
Some make a distinction between physical dependence and addiction, I don't per se.
Though there might have been a meaningful distinction once. There's a case for physical dependence from necessary use and addiction from non-necessary use of drugs. Because the former is likely to have its own challenges that aren't always the same as those who don't need to take medication for an original or underlying physical ailment.
The point of explaining this yet again is a feature of the current US opioid crisis is that people apparently didn't know opioids are inherently addicitve due to the nature of human biochemistry;
From 1996 to 2001, American drug giant Purdue Pharma held more than 40 national “pain management symposia” at picturesque locations, hosting thousands of American doctors, nurses and pharmacists. The healthcare professionals had been specially invited, whisked to the conferences to be drilled on promotional material about the firm’s new star drug, OxyContin, and recruited as advocates, the US government later documented.Don't doubt similar game isn't being played out with the 'obesity' cult, for "pain management" read "weight management." This quack cult is hell bent on creating a drug and surgery crises in the plural, in fat people, if we are dumb enough to allow them to have their way, again.
A bulletin from the American Public Health Association in 2009, reviewing the rise of prescription opioids, is titled “The promotion and marketing of OxyContin: commercial triumph, public health tragedy”. The document also asserted that Purdue had played down the risks of addiction."Played down the risks of addiction", um-hum, like playing down the risks of "stomach reduction surgery" and various prescription drug-abuse. That sort of thing can only make an impact if people no longer get what's being talked about, in this case, addiction.
Short Definition of Addiction:That's from the American Society of Addictive Medicine, playing the current trick of describing things in ways that obscures what is really being talked about. Does this definition help you to understand non-addictive opioid is chemically implausible? Do you understand it? Does it even make sense?
Addiction is a primary, chronic disease of brain reward, motivation, memory and related circuitry. Dysfunction in these circuits leads to characteristic biological, psychological, social and spiritual manifestations. This is reflected in an individual pathologically pursuing reward and/or relief by substance use and other behaviors.
If I wanted to know why exactly people got stuck on OxyContin and the like, how would "primary, chronic disease of brain reward, motivation, memory and related circuitry" help? Its agenda is concerned with selling addiction as a disease, rather than education. Note the same employ of phoney 'disease' in the area of weight.
Democracy Now on Oxycontin with Christopher Glazek